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    New treatment for kids with obesity

    Jonel Aleccia

    AP – Children struggling with obesity should be evaluated and treated early and aggressively, including with medications for kids as young as 12 and surgery for those as young as 13, according to new guidelines released on Monday.

    The longstanding practice of “watchful waiting”, or delaying treatment to see whether children and teens outgrow or overcome obesity on their own only worsens the problem that affects more than 14.4 million young people in the United States (US).

    Left untreated, obesity can lead to lifelong health problems, including high blood pressure, diabetes and depression.

    “Waiting doesn’t work,” said co-author of the first guidance on childhood obesity in 15 years from the American Academy of Paediatrics Dr Ihuoma Eneli. “What we see is a continuation of weight gain and the likelihood that they’ll have (obesity) in adulthood.”

    For the first time, the group’s guidance sets ages at which kids and teens should be offered medical treatments such as drugs and surgery – in addition to intensive diet, exercise and other behaviour and lifestyle interventions, said Director of the Centre for Healthy Weight and Nutrition Eneli at Nationwide Children’s Hospital in Columbus, Ohio.

    In general, doctors should offer adolescents 12 and older who have obesity access to appropriate drugs and teens 13 and older with severe obesity referrals for weight-loss surgery, though situations may vary.

    The guidelines aim to reset the inaccurate view of obesity as “a personal problem, maybe a failure of the person’s diligence”, said the medical director of the AAP Institute for Healthy Childhood Weight, and a co-author of the guidelines Dr Sandra Hassink.

    “This is not different than you have asthma and now we have an inhaler for you,” Hassink said.

    Young people who have a body mass index that meets or exceeds the 95th percentile for kids of the same age and gender are considered obese.

    Kids who reach or exceed that level by 120 per cent are considered to have severe obesity. BMI is a measure of body size based on a calculation of height and weight.

    Obesity affects nearly 20 per cent of kids and teens in the US and about 42 per cent of adults, according to the Centres for Disease Control and Prevention.

    The group’s guidance takes into consideration that obesity is a biological problem and that the condition is a complex, chronic disease, said Co-Director of the Centre for Pediatric Obesity Medicine at the University of Minnesota Aaron Kelly.

    “Obesity is not a lifestyle problem. It is not a lifestyle disease,” he said. “It predominately emerges from biological factors.”

    The guidelines come as new drug treatments for obesity in kids have emerged, including approval late last month of Wegovy, a weekly injection, for use in children ages 12 and older.

    Different doses of the drug, called semaglutide, are also used under different names to treat diabetes.

    A recent study published in the New England Journal of Medicine found that Wegovy, made by Novo Nordisk, helped teens reduce their BMI by about 16 per cent on average, better than the results in adults.

    Within days of the December 23 authorisation, paediatrician Dr Claudia Fox had prescribed the drug for one of her patients, a 12-year-old girl.

    “What it offers patients is the possibility of even having an almost normal body mass index,” said Fox, also a weight management specialist at the University of Minnesota. “It’s like a whole different level of improvement.”

    The drug affects how the pathways between the brain and the gut regulate energy, said, an obesity researcher at Lurie Children’s Hospital in Chicago Dr Justin Ryder.

    “It works on how your brain and stomach communicate with one another and helps you feel more full than you would be,” he said.

    Still, specific doses of semaglutide and other anti-obesity drugs have been hard to get because of recent shortages caused by manufacturing problems and high demand, spurred in part by celebrities on TikTok and other social media platforms boasting about enhanced weight loss. In addition, many insurers won’t pay for the medication, which costs about USD1,300 a month.

    “I sent the prescription yesterday,” Fox said. “I’m not holding my breath that insurance will cover it.”

    One expert in pediatric obesity cautioned that while kids with obesity must be treated early and intensively, he worries that some doctors may turn too quickly to drugs or surgery.

    “It’s not that I’m against the medications,” said a longtime specialist in paediatric endocrinology at the University of California, San Francisco Dr Robert Lustig. “I’m against the willy-nilly use of those medications without addressing the cause of the problem.”

    Lustig said children must be evaluated individually to understand all of the factors that contribute to obesity.

    He has long blamed too much sugar for the rise in obesity. He urges a sharp focus on diet, particularly ultra-processed food that are high in sugar and low in fibre.

    A paediatrician at Cedars Sinai Medical Centre in Los Angeles Dr Stephanie Byrne said she’d like more research about the drug’s efficacy in a more diverse group of children and about potential long-term effects before she begins prescribing it regularly.

    “I would want to see it be used on a little more consistent basis,” she said. “And I would have to have that patient come in pretty frequently to be monitored.”

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