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‘Never seen anything like what’s happening’

LONDON (AP) – Scientists who have monitored numerous outbreaks of monkeypox in Africa said they are baffled by the disease’s recent spread in Europe and North America.

Cases of the smallpox-related disease have previously been seen only among people with links to central and West Africa. But in the past week, Britain, Spain, Portugal, Italy, United States (US), Sweden and Canada all reported infections, mostly in young men who hadn’t previously travelled to Africa.

There are about 80 confirmed cases worldwide and 50 more suspected ones, the World Health Organization (WHO) said. France, Germany, Belgium and Australia reported their first cases on Friday.

“I’m stunned by this. Every day I wake up and there are more countries infected,” said virologist Oyewale Tomori, who formerly headed the Nigerian Academy of Science and who sits on several WHO advisory boards.

“This is not the kind of spread we’ve seen in West Africa, so there may be something new happening in the West,” he said.

To date, no one has died in the outbreak. Monkeypox typically causes fever, chills, rash and lesions on the face or genitals. WHO estimates the disease is fatal for up to one in 10 people, but smallpox vaccines are protective and some antiviral drugs are being developed.

Spallanzani infectious disease hospital director Francesco Vaia talks to reporters during a press conference, in Rome; and the arms and torso of a patient who’s skin displayed a number of lesions due to monkeypox. PHOTOS: AP

British health officials are exploring whether the disease is being sexually transmitted. Health officials have asked doctors and nurses to be on alert for potential cases, but said the risk to the general population is low.

The European Center for Disease Control and Prevention recommended all suspected cases be isolated and that high-risk contacts be offered smallpox vaccine.

Nigeria reports about 3,000 monkeypox cases a year, WHO said. Outbreaks are usually in rural areas, when people have close contact with infected rats and squirrels, Tomori said. He said many cases are likely missed.

Head of the country’s Center for Disease Control Dr Ifedayo Adetifa said none of the Nigerian contacts of the British patients have developed symptoms and that investigations were ongoing.

WHO’s Europe director, Dr Hans Kluge, described the outbreak as “atypical”, saying the disease’s appearance in so many countries across the continent suggested that “transmission has been ongoing for some time”. He said most of the European cases are mild.

On Friday, Britain’s Health Security Agency reported 11 new monkeypox cases.

In Germany, Health Minister Karl Lauterbach said the government was confident the outbreak could be contained.

He said the virus was being sequenced to see if there were any genetic changes that might have made it more infectious.

Infectious diseases professor Rolf Gustafson told Swedish broadcaster SVT that it was “very difficult” to imagine the situation worsening.

“We will certainly find some further cases in Sweden, but I do not think there will be an epidemic in any way,” Gustafson said. “There is nothing to suggest that at present.”

Scientists said that while it’s possible the outbreak’s first patient caught the disease while in Africa, what’s happening now is exceptional.

“We’ve never seen anything like what’s happening in Europe,” said Director of the African Centre of Excellence for Genomics of Infectious Diseases Christian Happi.

“We haven’t seen anything to say that the transmission patterns of monkeypox have been changing in Africa. So if something different is happening in Europe, then Europe needs to investigate that.”

Happi also pointed out that the suspension of smallpox vaccination campaigns after the disease was eradicated in 1980 might inadvertently be helping monkey-pox spread.

Smallpox vaccines also protect against monkeypox, but mass immunisation stopped decades ago.

“Aside from people in west and Central Africa who may have some immunity to monkeypox from past exposure, not having any smallpox vaccination means nobody has any kind of immunity to monkeypox,” Happi said.

Professor of vaccinology at the University of Witwatersrand in Johannesburg Shabir Mahdi said a detailed investigation of the outbreak in Europe, including determining who the first patients were, was now critical.

“We need to really understand how this first started and why the virus is now gaining traction,” he said. “In Africa, there have been very controlled and infrequent outbreaks of monkeypox. If that’s now changing, we really need to understand why.”