CANBERRA (XINHUA) – A specific type of DNA structure could be key in regulating how the brain forms memories, Australian research has found.
In a study published recently, international researchers led by a team from the Australian National University (ANU) discovered that G-quadruplex DNA (G4-DNA) plays a role in transcribing memories.
G4-DNA is generally found in cells when DNA sequences fold into a different, four-stranded structure.
It is usually associated with DNA damage and is frequently observed in cancer cells.
Lead author of the study from the ANU College of Health and Medicine Paul Marshall said that G4-DNA’s involvement in stalling the basic functions of some cells had previously been discovered but that the new findings were the first evidence of its role in making new memories. The study found that the accumulation of G4-DNA in neurons in the brain is required for the activation and silencing of genes that are critically involved in learning and memory.
“We found that casually manipulating G4-DNA can lead to a substantial impairment in memory,” Marshall said in a media release.
“But in other scenarios it can result in increased transcription. It can have different effects on memory depending on the area of the brain, and type of memory involved.
The research was conducted on living cells from mice in collaboration with scientists from the University of Queensland, Linköping University in Sweden, the Weizmann Institute of Science and the University of California.
